MR spectroscopy of amygdala: space saturation technique improves spectral quality.1Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
AbstractOBJECTIVE: To investigate the effect of space saturation technique on the quality of proton magnetic resonance spectroscopy （1 H-MRS） for amygdala. METHODS: 22 healthy volunteers were enrolled and scanned at a 3.0T MR scanner. Single voxel H-MRS of amygdala with and without space saturation bands around the region of interest was performed using point-resolved spectroscopy series （PRESS, TR/TE = 1500/30 ms）. Raw spectral data were processed and signal-to-noise ratio of creatine （Cr-SNR）, water-suppression level, full width at half maximum （FWHM） and root mean square （RMS） noise were obtained and compared between groups with and without saturation bands. RESULTS: The Cr-SNR of spectra without and with saturation bands was 15.506 +/- 6.623 and 22.935 +/- 7.270, respectively [increased by （47.9% +/- 24.94%）, P < 0.001]. The water-suppression level of spectra without and with saturation bands was （93.888% +/- 1.079%） and （95.722% +/- 0.461%）, respectively [increased by （1.95% +/- 0.68%）, P < 0.001]. The FWHM of spectra without and with saturation bands was 7.00 +/- 1.113 and 6.82 +/- 1.181, respectively [decreased by （2.57% +/- 1.12%）, P > 0.053. The RMS noise of spectra without and with saturation bands was 0.606 +/- 0.0615 and 0.589 +/- 0.0470, respectively [reduced by （2.81% +/- 1.68%）, P > 0.053. CONCLUSION: Application of space saturation technique significantly elevates the Cr-SNR and the water-suppression level, and thus improves the spectral quality of amygdala without additional scanning time. Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Mar;42（2）:269-72. PMID: 21500570 [PubMed - indexed for MEDLINE]
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