Rigid Mn（II） chelate as efficient MRI contrast agent for vascular imaging.

Su H¹, Wu C, Zhu J, Miao T, Wang D, Xia C, Zhao X, Gong Q, Song B, Ai H.

Author information

• ¹National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, PR China.

Abstract

The aza-semi-crown pentadentate ligand rigidified by pyridine and piperidine rings was designed and synthesized. It can react with Mn（II） in water to form complex with improved longitudinal relaxivity, leading to efficient signal intensity enhancement of vascular vessels under a clinical magnetic resonance imaging scanner.

Dalton Trans. 2012 Dec 28;41（48）:14480-3. doi: 10.1039/c2dt31696j.