武汉同济医院李小明 Magnetic resonance evaluation of renal artery stenosis in a swine model: performance of low-dose gadobutrol versus gadoterate meglumine in comparison with digital subtraction intra-arterial

Invest Radiol. 2012 Jun;47（6）:376-82. doi: 10.1097/RLI.0b013e3182539554.

Magnetic resonance evaluation of renal artery stenosis in a swine model: performance of low-dose gadobutrol versus gadoterate meglumine in comparison with digital subtraction intra-arterial catheter angiography.

Morelli JN¹, Runge VM, Ai F, Zhang W, Li X, Schmitt P, McNeal G, Miller M, Lennox M, Wusten O, Schoenberg SO, Attenberger UI.

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Abstract

PURPOSE:

The aim of this study was to compare low-dose imaging with gadobutrol and gadoterate meglumine （Gd-DOTA） for evaluation of renal artery stenosis with 3-T magnetic resonance angiography （MRA） in a swine model.

METHOD AND MATERIALS:

A total of 12 experimental animals were evaluated using equivalently dosed gadobutrol and Gd-DOTA for time-resolved and static imaging. For time-resolved imaging, the time-resolved imaging with stochastic trajectories （TWIST） technique （temporal footprint, 4.4 seconds） was used; a dose of 1 mL of gadobutrol was injected at 2 mL/s and a dose of 2 mL of Gd-DOTA was injected at both 2 and 4 mL/s. For a separate static acquisition, doses were doubled. The static scans were used for stenosis gradation and the time-resolved scans for comparison of enhancement dynamics, signal-to-noise ratio （SNR）, and qualitative assessments.

RESULTS:

The average magnitude of difference in the stenosis measurements with static gadobutrol scans relative to digital subtraction intra-arterial catheter angiography （mean [SD], 7.4% [5.6%]） was less than with both the 2 mL/s （10.6% [6.2%]） and 4 mL/s （11.5% [7.8%]） Gd-DOTA MRA protocols. On time-resolved scans, peak signal-to-noise ratio was greatest with the gadobutrol protocol （P < 0.05）, and the gadobutrol TWIST scan was preferred to the TWIST Gd-DOTA scan in terms of image quality and stenosis visualization in every case for every reader.

CONCLUSION:

Low-dose gadobutrol （~0.05 mmoL/kg） contrast-enhanced MRA results in improved accuracy of renal artery stenosis assessments relative to equivalently dosed Gd-DOTA at 3 T.

PMID: 22543971 DOI: 10.1097/RLI.0b013e3182539554 [PubMed - indexed for MEDLINE]