武汉同济医院胡道予 Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study

Wang Y， Hu S， Hu X， et al.

Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study[J]. Oncology， 2015， 4: 005.

Abstract：Objective The aim of this study was to investigate the ability of intravoxel incoherent motion （IVIM） dif usion-weighted magnetic resonance imaging （MRI） to diagnose cervical cancer and to evaluate the response of uterine cervical cancer to radiochemotherapy （CRT）. Methods This prospective study was approved by the institutional review board， and informed consent was obtained from al patients. A total of 23 patients with primary cervical cancer who were undergoing CRT and 16 age-matched healthy subjects were prospectively recruited for IVIM （b = 0–800 s/mm2） and stan-dard pelvic MRI. Bi-exponential analysis was performed to derive f （perfusion fraction）， D* （pseudo-dif usion coef icient）， and D （true molecular dif usion coef icient） in cervical cancer （n = 23） and the normal cervix （n= 16）. The apparent dif usion coef icient （standard ADC） was calculated. The independent-samples t-test and paired-samples t-test were used for comparisons. Results Pre-treatment cervical cancer had the lowest standard ADC （1.15 ± 0.13 × 10-3 mm2/s） and D （0.89 ± 0.10 × 10-3 mm2/s） values， and these were significantly dif erent from the normal cervix and post-treatment cervical cancer （P = 0.00）. The f （16.67 ± 5.85%） was lowest in pre-treatment cervical cancer and was significantly dif erent from the normal cervix and post-treatment cervical cancer （p = 0.012 and 0.00， respectively）. No dif erence was observed in D*. Conclusion IVIM is potential y promising for dif erentiating between the normal cervix and cervical can-cer because pre-treated cervical cancer has low perfusion and dif usion IVIM characteristics. Further， the standard ADC， D， and f of cervical cancer showed a tendency to normalize after CRT; thus， IVIM may be useful for monitoring the response to CRT in cervical cancer.

doi：10.1007/s10330-015-0105-9