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Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Jul;43（4）:601-4. [Comparison of the efficacy of gadobutrol and multihance in contrast-enhanced MRI for diagnosis of brain metastasis in lung cancer]. [Article in Chinese] Li ZL1, Chen X, Xia CC, Sun JY, Li CX, Tang HH, Song B. Author information 1Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract OBJECTIVE: To investigate the diagnostic efficacy of gadobutrol for assessing brain metastases in lung cancer patients in comparison with multihance. METHODS: 21 patients with lung cancer suspected of brain metastasis were enrolled in this study. All patients underwent twice MRI scans on a 3.0T MRI scanner （Siemens MAGENETOM Trio） with 8-channel head coil, first with 0.5 mol/L multihance and then with 1.0 mol/L gadobutrol as contrast agent. The dosage of contrast agent was set at 0.1 mmol/kg body mass. The interval between the two scans was 24-72 hours. The detection and delineation of lesions were evaluated visually. The signal-to-noise ratios （SNR）, contrast-to-noise ratios （CNR） of lesion to normal brain white matter and the percentage of lesion enhancement were calculated and compared between the two scans by 2 experienced neuroradiologists. RESULTS: One patient was excluded because he received radiation therapy between the two scans. 15 patients were found to have brain metastases with a total of 35 lesions. There were no statistical differences between the two scans in SNR, CNR and percentage enhancement for both normal brain and lesions （t = 0.545, P = 0.592; t = 1.143, P = 2.267; t = 0.592, P = 0.557; t = 0.473, P = 0.639）. CONCLUSION: Half-dose gadobutrol （1.0 mol/L） can achieve the same enhancement effects compared with full-dose multihance （0.5 mol/L）. PMID: 22997905
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