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Eur J Radiol. 2012 Jul;81（7）:1426-31. doi: 10.1016/j.ejrad.2011.03.045. Epub 2011 Apr 5. Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI. Yin WJ1, Liu F, Li XM, Yang L, Zhao S, Huang ZX, Huang YQ, Liu RB. Author information 1Department of Radiology, West China Hospital of Sichuan University, No 37 Guoxue Street, Wuhou District, Chengdu, Sichuan 610041, China.
Abstract PURPOSE: To evaluate the renal oxygenation in type 2 diabetes by blood oxygenation level dependent magnetic resonance imaging （BOLD-MRI）. MATERIALS AND METHODS: Forty-eight patients with type 2 diabetes and 67 healthy controls were recruited. All patients were further divided into four subgroups based on renal functional level. Bilateral renal cortical R2* （CR2*） and medullary R2* （MR2*） values were extracted and quantified on BOLD-MRI, then R2* ratio between medulla and cortex （MCR） was calculated. CR2*, MR2* and MCR were compared among the groups separately. The relationships were analyzed between R2* values and clinical index of renal function. RESULTS: Compared with controls, MR2* and CR2* in diabetes were significantly increased. The positive relationship was found between MR2* and estimated glomerular filtration rate （eGFR）, and CR2* was negatively correlated with eGFR. Interestingly, the MCR increased in early stage of diabetes and decreased along with the aggravation of diabetic nephropathy （DN）. CONCLUSION: BOLD-MRI can non-invasively detect and assess the renal hypoxia in diabetes. Our findings suggest that hypoxia in medulla is more apparent and earlier than in cortex. During the progression of DN, a reversion of corticomedullary oxygenation gradient can be detected, thus, MCR would be adopted to suppose the progression and prognosis of DN. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. PMID: 21470811 [PubMed - indexed for MEDLINE]
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