华西医院刘荣波 Diffusion-weighted imaging of the kidneys and its relationship with residual renal function in continuous ambulatory peritoneal dialysis patients.

AJR Am J Roentgenol. 2015 May;204（5）:1008-12. doi: 10.2214/AJR.13.12440.

Diffusion-weighted imaging of the kidneys and its relationship with residual renal function in continuous ambulatory peritoneal dialysis patients.

Yang L¹, Li XM, Zhao S, Hu YJ, Liu RB.

Author information

• ¹Department of Radiology, West China Hospital, Sichuan University, 37 Guoxue St, Chengdu 610041, Sichuan Province, China.

Abstract

OBJECTIVE:

The objective of our study was to prospectively evaluate renal diffusion as shown by diffusion-weighted imaging （DWI） and its relationship with the residual renal function （RRF） in continuous ambulatory peritoneal dialysis （CAPD） patients.

SUBJECTS AND METHODS:

Forty CAPD patients and 40 healthy volunteers were recruited, and all underwent conventional and fat-saturated echo-planar DWI with three b values （0, 300, 600 s/mm（2））. The renal parenchymal thickness and apparent diffusion coefficients （ADCs） were measured, and both were compared between the two groups. The relationships between ADC values and clinical indexes--which included RRF, serum creatinine value, cystatin C value, and urine output--were analyzed.

RESULTS:

Compared with the renal parenchymal thickness and ADC values in control subjects, these values in CAPD patients were significantly decreased （p < 0.0001）. In CAPD patients, the ADC values were positively correlated with RRF （r = 0.447, p = 0.004）. A mild linear correlation was also found between the ADC values and cystatin C value （r = -0.352, p = 0.026）.

CONCLUSION:

The renal diffusion function as shown by DWI is impaired in CAPD patients and correlates with RRF.

KEYWORDS:

apparent diffusion coefficient; continuous ambulatory peritoneal dialysis; diffusion-weighted imaging; residual renal function

PMID: 25905935  [PubMed - indexed for MEDLINE]