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J Comput Assist Tomogr. 2013 Jan-Feb;37（1）:105-10. doi: 10.1097/RCT.0b013e318276fc92. Contrast dose, temporal footprint, and spatial resolution tradeoffs in dynamic contrast-enhanced MRAperformed in a porcine model of a carotid aneurysm. Ai T1, Goerner F, Patel N, Trelles M, Wu G, Li X, Runge VM. Author information Abstract OBJECTIVE: To evaluate the tradeoffs between temporal and spatial resolution and contrast dosing in dynamic contrast-enhanced magnetic resonance angiography （CE-MRA）. METHODS: Bilateral carotid artery aneurysms were created in a swine model. Dynamic CE-MRA using 1 mol/L gadobutrol was performed at 3 T, with high temporal （high-temp）, middle temporal （mid-temp）, and low temporal （low-temp） resolutions. High temporal CE-MRA was performed twice using 1 mL and 2 mL gadobutrol （2 mL/s）. Middle temporal and low-temp sequences were performed once with 2 mL gadobutrol （2 mL/s）. The signal-to-noise ratio （SNR） was quantitatively assessed. Blinded reads were used to qualitatively evaluate contrast dose and image quality. RESULTS: The mean SNRs of high-temp, mid-temp, and low-temp resolutions were 56.7, 47.5, and 48.1. There was no significant difference between the 3 sequences with 2 mL gadobutrol. The mean SNR of the high-temp resolution with 2 mL was significantly higher than that with 1 mL （56.7 vs 39.9）. In qualitative analysis, the 3 temporal sequences with 2 mL gadobutrol showed no significant differences regarding overall image quality and diagnostic value. High temporal resolution with 2 mL consistently showed the superiority of image quality than that with 1 mL. CONCLUSIONS: High temporal dynamic CE-MRA with 2 mL （0.04 mmol/kg body weight） gadobutrol can produce consistently superior image quality over that with 1 mL （0.02 mmol/kg body weight）. For a given contrast dose, the tradeoffs between temporal and spatial resolution will not result in significant differences in image quality in TWIST （time-resolved angiography with interleaved stochastic trajectories）. PMID: 23321841 DOI: 10.1097/RCT.0b013e318276fc92 [PubMed - indexed for MEDLINE]
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