Assessment of disease activity and liver fibrosis in chronic viral hepatitis by magnetic resonance diffusion-weighted imaging.1Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
AbstractOBJECTIVE: To investigate the diagnostic value of magnetic resonance diffusion-weighted imaging （DWI） technique in assessing the disease activity and liver fibrosis of chronic viral hepatitis. METHODS: A total of 49 patients with chronic viral hepatitis who received liver biopsy and 10 healthy volunteers were included in this study. All of them underwent DWI on a 3.0 T magnetic resonance imaging system. When the gradient factor b value was set at 100, 200, 400, 600, and 800 s/mm2, the apparent diffusion coefficient （ADC） of the liver was measured respectively. Biopsy specimens were scored for necroinflammation and liver fibrosis according to the Knodell histological activity index. RESULTS: The ADC values of the right lobe in both controls and patients were lower than those of the left lobe. When the b value was set at 400, 600, and 800 s/mm2, the differences of the ADC values between the fibrosis group （n = 36） and the non-fibrosis group （n = 23, including 10 cases of normal subjects） were statistically significant （P < 0.01）. When the b value was set at 800 s/mm2, the ADC values among the different degrees of necroinflammation and grades of liver fibrosis were also significantly different （P < 0.05, P < 0.01）. CONCLUSION: DWI is a valuable method for in vivo and noninvasive assessment of the disease activity and liver fibrosis of chronic viral hepatitis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Apr;31（2）:155-9. PMID: 19507592 [PubMed - indexed for MEDLINE]
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