Change in renal parenchymal volume in living kidney transplant donorsAuthor information 1Department of Urology, West China Hospital, Sichuan University, Guoxue Xiang #37, Chengdu, 610041, Sichuan, People's Republic of China.
Abstract PURPOSE: Uninephrectomy would induce compensatory hypertrophy in the remaining kidney. We investigated the relationship between changes in renal parenchymal volume （RPV） and renal function after nephrectomy in living kidney donors. METHODS: From July 2011 and January 2012, 45 kidney donors were enrolled in this study. Magnetic resonance scanning was performed before surgery, 3 and 7 days postoperatively, and RPV was calculated through disc summarize methods. Participants were followed up for 1 year. RESULTS: The RPV of the remaining kidney was 118.06 ± 23.51 cm（3） and then increased by 21.23 % to 143.13 ± 25.52 cm（3） at 3 days and by 24.17 % to 146.60 ± 25.86 cm（3） at 7 days. Multivariate regression analysis showed that preoperative RPV is positively related to its initial function （p = 0.037）; the RPV at 7 days is directly related to its initial, preoperative size （p < 0.001）. With respect to change in postoperative RPV, there is bigger gain in size in smaller kidneys （p = 0.005）. The kidneys that has ≥20 % increase RPV after 7 days are more likely to show further increase in GFR at 1 year （p = 0.024）. CONCLUSIONS: Uninephrectomy induced immediately increment in RPV of the remaining kidney. Donors with RPV increase of ≥20 % at 1 week have a more favourable renal function adaptation at 1 year. See comment in PubMed Commons belowInt Urol Nephrol. 2014 Apr;46（4）:743-7. doi: 10.1007/s11255-013-0592-y. Epub 2013 Nov 1. PMID: 24178754 [PubMed - indexed for MEDLINE]
|
e学e用