Assessment of intrarenal oxygenation in renal donor with blood oxygenation level-dependent magnetic resonance imaging

Song T1, Lin T1, Huang Z2, Fu L1, He S1, Song B2, Wei Q3.

Author information

  • 1Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

  • 2Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

  • 3Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: liangrenliu@126.com.

Abstract

OBJECTIVE:

To examine change of the apparent relaxation rate R2* values in living kidney donors after uninephrectomy using blood oxygenation level-dependent magnetic resonance imaging.

METHODS:

Between July 2011 and January 2012, 45 kidney donors were enrolled into this study. Blood oxygenation level-dependent magnetic resonance imaging scanning was performed before surgery, 3 and 7 days postoperatively. Participants were followed up for 1 year.

RESULTS:

The R2* values in medulla mR2* were significantly greater than that of cortex cR2*, both in resected kidney and remaining one. cR2* values of the remaining kidney was 17.52 ± 1.36 s-1 and then decrease significantly by 8.97% to 15.95 ± 1.14 s-1 at 3 days P <.001 and by 7.82% to 16.15 ± of 1.05 s-1 at 7 days. No significant modification occurred in mR2* after surgery. Multivariate regression analysis showed that the decrease in cR2* values of the remaining kidney was positively associated with sex r = 0.418, body surface area r = 0.307, and preoperative cR2* values r = 0.659. Comparing with glomerular filtration rate at 7 days, a further increment in the glomerular filtration rate was noted at 1 year in patients with cR2* values decrease of ≥ 10% at 1 week 62.63 ± 11.69 vs 56.97 ± 7.51 mL/min/1.73 m2, P = .02 but not in the other patients 66.43 ± 10.89 vs 62.78 ± 13.74, P = .064.

CONCLUSION:

Kidney donation will induce early, profound oxygenation modification within the renal cortex of the remaining kidney. Donors with cR2* value decrease of ≥ 10% at 1 week have a more favorable renal function compensation at 1 year.

Copyright © 2014 Elsevier Inc. All rights reserved.

 

Urology. 2014 May;835:1205.e1-5. doi: 10.1016/j.urology.2014.01.015. Epub 2014 Mar 25.

PMID: 24680611 [PubMed - indexed for MEDLINE]

 

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